Is The Variant From India The Most Contagious Coronavirus Mutant On The Planet?

Juan Gaertner/Science Source

The small numerals in the illustration show the main mutation sites of the variant B.1.1.7 found in the U.K., which is more transmissible than other versions. In the depiction, the spike protein of the virus (red) is bound to a human cell (blue).

Back in the fall, Tom Wenseleers made a bold claim on Twitter. He tweeted that the new coronavirus variant emerging in the U.K. was more transmissible — or could spread more quickly — than over versions of the virus.

“I posted a graph [on Twitter] showing the U.K. variant had a transmission advantage over the other types of the virus,” says Wenseleers, an evolutionary biologist at the University of Leuven in Belgium.

At first, many scientists didn’t believe his analysis. Many people thought the big COVID-19 surge in England was due to holiday travel and shopping, he says. But after many follow-up studies, Wenseleers’ take proved correct. The variant first detected in the U.K., called B.1.1.7, is indeed more transmissible and likely the most contagious version of the virus known.

Now Wenseleers has performed similar analyses on data from India, and he’s feeling a bit of a déjà vu.

“Based on this data, the new variant from India has a very big transmission or growth advantage,” even over B.1.1.7, he says. “It’s kind of like the U.K. variant squared.”

This advantage, Wenseleers believes, is fueling the massive outbreak in India, on top of other contributing factors, such as recent mass gatherings, election rallies and relaxing of precautions.

Over the winter, the situation in India looked great. COVID-19 case numbers were flat and even dropping.

Then in the middle of February and early March, the situation quickly shifted. The virus surged explosively. Now India is battling a horrific second wave of COVID-19, reporting about 400,000 cases and more than 3,500 deaths every day.

At the same time, the new variant that emerged in India, known as B.1.617, began to dominate the outbreak in several Indian states. This variant has more than a dozen mutations, including several known to enhance transmissibility and help the virus evade the immune system.

Other variants are also circulating in India, including B.1.351 from South Africa and B.1.1.7 from the U.K. To figure out which variant is spreading the fastest, Wenseleers used a mathematical model to estimate how quickly cases of each variant are rising in several regions. He found cases of B.1.617 to be rising at a faster rate than cases of B.1.1.7 in three states in India as well as in the United Kingdom.

“If you take all these pieces of evidence together, I’m fairly confident that the variant from India has a growth advantage and that is a reason for the current epidemic in India,” he says.

Of course, there are several caveats here. The findings are preliminary and haven’t been published, except on Twitter. “And the data are still very limited,” he says. “The number of variant sequences that’s available for India is quite small, especially considering the size of the country and the population.”

For these reasons, other researchers are again dubious of Wenseleers’ findings.

Karthik Gangavarapu, who’s a computational biologist at Scripps Research Institute, is one of them. “I don’t think the story is clear yet,” he says. “I’m not saying B.1.617 isn’t more transmissible than B.1.1.7, I’m just saying there’s a burden of proof you need to establish before you can say that.”

Still though, Gangavarapu says, there’s no question the variant that emerged in India is worrisome — and something the whole world needs to try and stop together.

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